The Typhoid IgG/IgM Rapid Test Cassette is a rapid, qualitative and differential test for the detection of IgG and IgM antibodies to Salmonella typhi (S. typhi) and paratyphi in human serum or plasma. It is for in vitro diagnostic use only and is intended as an aid in the earlier diagnosis of infection with S. typhi and paratyphi. The results obtained should not be the sole determinant for clinical decision. All positive specimens must be confirmed with other confirmation methods.

Typhoid fever and paratyphi fever are bacterial infections caused by Salmonella Typhi and parathyphoid A, B, C respectively, which is transmitted through the ingestion of tainted food and water. World-wide an estimated 17 million cases and 600,000 associated deaths occur annually. Patients who are infected with HIV are at significantly increased risk for clinical infection. 1 - 5% of patients become chronic carriers harboring S. typhi in the gallbladder. The clinical diagnosis of infections depends on isolation of S. typhi and paratyphi from blood, bone marrow or a specific anatomic lesion. In facilities that cannot afford to perform this complicated and time-consuming procedure, Filix-Widal test is used to facilitate diagnosis. However, many limitations lead to difficulties in the interpretation of the Widal test.